Continuous and intermittent exposure of neonatal rat calvarial cells to PTHrP (1-36) inhibits bone nodule mineralization in vitro by downregulating bone sialoprotein expression via the cAMP signaling pathway

Name	World Continuing Education Alliance
Activity Title	Continuous and intermittent exposure of neonatal rat calvarial cells to PTHrP (1-36) inhibits bone nodule mineralization in vitro by downregulating bone sialoprotein expression via the cAMP signaling pathway
Details	Parathyroid-hormone-related protein (PTHrP) is the causative factor of humoral hypercalcemia of malignancy. The amino terminus of PTHrP has strong homology with the comparable region of parathyroid hormone (PTH). In several tissues, including bone, it has been reported that PTHrP and PTH1R mRNAs and/or proteins are expressed by adjacent, but different, cell populationsn Objectives Course Objective The development and growth of the skeleton in the absence of parathyroid-hormone-related protein (PTHrP) is abnormal. The shortening of appendicular bones in PTHrP gene null mice is explained by an effect of PTHrP on endochondral bone growth. Whether or not PTHrP influences intramembranous ossification is less clear. The purpose of this study was to determine the effect of exogenous PTHrP on intramembranous ossification n
Competence	Public Health
Start Date	<span class="not-set">(not set)</span>
End Date	<span class="not-set">(not set)</span>
Event Time	01:45 PM
Location	World Continuing Education Alliance eLearning System
Cost (UGX)	0
CPD Points	1